Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/109007
Title: One-carbon metabolism nutrient status and plasma s-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore
Authors: Inoue-Choi, M.
Nelson, H.H.
Robien, K.
Arning, E.
Bottiglieri, T.
Koh, W.-P. 
Yuan, J.-M.
Keywords: MAT genetic polymorphism
One-carbon metabolism
Path analysis
Plasma SAM
Issue Date: 2012
Source: Inoue-Choi, M.,Nelson, H.H.,Robien, K.,Arning, E.,Bottiglieri, T.,Koh, W.-P.,Yuan, J.-M. (2012). One-carbon metabolism nutrient status and plasma s-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore. International Journal of Molecular Epidemiology and Genetics 3 (2) : 160-173. ScholarBank@NUS Repository.
Abstract: S-adenosylmethionine (SAM) is a primary methyl donor for the methylation of many molecules including DNA. DNA methylation is believed to play an important role in functions of cells and genes. Dietary, genetic and metabolic factors that influence systematic SAM levels are not fully understood. We conducted cross-sectional analysis to evaluate associations between plasma concentrations of one-carbon metabolism nutrients and metabolites and plasma SAM concentrations using healthy individuals within the Singapore Chinese Health Study. Plasma SAM, be-taine, choline, folate, total homocysteine (Hcy), methionine, S-adenosylhomocysteine (SAH), vitamin B6 and vitamin B12 concentrations were quantified. Genotypes of methionine adenosyltransferases (MAT1A, MAT2A and MAT2B) were also determined. Linear regression and path analysis were performed to depict the directed dependencies in one-carbon metabolism. Age and body mass index were positively associated while cigarette smoking were inversely associated with plasma SAM concentrations. Plasma choline, methionine and SAH were positively and strongly associated with plasma SAM after adjustment for confounders. Plasma betaine and folate were positively associated with plasma SAM only in men. Men carrying the variant MAT1A genotypes had lower plasma SAM concentrations than men carrying the wild type genotype (p for gene x gender interaction = 0.02). This effect modification by gender was restricted to individuals with low plasma methionine. In conclusion, plasma choline, methionine and SAH were strongly associated with plasma SAM concentrations. The MAT1A genetic polymorphism may impact plasma SAM concentrations in men with low plasma methionine concentrations.
Source Title: International Journal of Molecular Epidemiology and Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/109007
ISSN: 19481756
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

24
checked on Feb 16, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.