Please use this identifier to cite or link to this item: https://doi.org/10.1158/1055-9965.EPI-12-0138-T
Title: Mitochondrial copy number is associated with colorectal cancer risk
Authors: Thyagarajan, B.
Wang, R.
Barcelo, H.
Koh, W.-P. 
Yuan, J.-M.
Issue Date: Sep-2012
Source: Thyagarajan, B., Wang, R., Barcelo, H., Koh, W.-P., Yuan, J.-M. (2012-09). Mitochondrial copy number is associated with colorectal cancer risk. Cancer Epidemiology Biomarkers and Prevention 21 (9) : 1574-1581. ScholarBank@NUS Repository. https://doi.org/10.1158/1055-9965.EPI-12-0138-T
Abstract: Background: Mitochondria are eukaryotic organelles responsible for energy production. Quantitative changes in human mitochondrial DNA (mtDNA) copy number have been implicated in various cancer types. Data from prospective cohort studies on mtDNA copy number and colorectal cancer risk have been lacking. Methods: We evaluated the association between mtDNA copy number in peripheral blood and colorectal cancer risk in a nested case-control study of 422 colorectal cancer cases (168 cases with pre-diagnostic blood and 254 cases with post-diagnostic blood) and 874 controls who were free of colorectal cancer among participants of the Singapore Chinese Health Study. The relative mtDNA copy number was measured using real-time PCR. Unconditional logistic regression methods were employed to examine the association between mtDNA copy number and colorectal cancer risk. Results: There was a U-shaped relationship between the relativemtDNAcopy number and colorectal cancer risk. Compared with the 2nd quartile, the OR (95% confidence intervals) for subjects in the lowest and highest quartiles of relative mtDNA copy numbers were 1.81 (1.13-2.89) and 3.40 (2.15-5.36), respectively (Pcurvilinearity
Source Title: Cancer Epidemiology Biomarkers and Prevention
URI: http://scholarbank.nus.edu.sg/handle/10635/108992
ISSN: 10559965
DOI: 10.1158/1055-9965.EPI-12-0138-T
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

46
checked on Apr 23, 2018

WEB OF SCIENCETM
Citations

43
checked on Apr 23, 2018

Page view(s)

19
checked on Mar 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.