Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.prostaglandins.2013.08.003
Title: Exploratory investigation reveals parallel alteration of plasma fatty acids and eicosanoids in coronary artery disease patients
Authors: Xu, Y.-J.
Ho, W.E.
Xu, F.
Wen, T.
Ong, C.N. 
Keywords: Cardiovascular diseases
Eicosanoids
Fatty acids
GC/MS
LC/MS
Lipids
Issue Date: 2013
Citation: Xu, Y.-J., Ho, W.E., Xu, F., Wen, T., Ong, C.N. (2013). Exploratory investigation reveals parallel alteration of plasma fatty acids and eicosanoids in coronary artery disease patients. Prostaglandins and Other Lipid Mediators 106 (1) : 29-36. ScholarBank@NUS Repository. https://doi.org/10.1016/j.prostaglandins.2013.08.003
Abstract: Fatty acids and eicosanoids are two important classes of signaling lipid molecules involved in the pathogenesis of cardiovascular diseases. To investigate the physiological functions and interplay between fatty acids and eicosanoids in coronary artery disease (CAD) patients, we developed an analytical approach for parallel quantitative analysis of plasma fatty acids and eicosanoids, using gas chromatography-tandem mass spectrometry (GC-MS/MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). In this study, 26 fatty acids and 12 eicosanoids were confidently detected in 12 patients with confirmed coronary artery disease and 11 healthy subjects. Pattern recognition analysis (principal components analysis, orthogonal partial least-square discriminate analysis, and hierarchical clustering analysis) demonstrated that the plasma lipid profile of fatty acids and eicosanoids enabled robust discrimination of CAD patients versus healthy subjects. Significant differences in six fatty acids and five eicosanoids were noted among CAD patients and healthy subjects. The development of cardiovascular disease-induced metabolic change of fatty acids and eicosanoids, such as eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, hydroxyeicosatetraenoic acids and hydroxyoctadecadienoic acid, were consistent with previous isolated observations. Moderate-strong correlations between three plasma fatty acids and three eicosanoids from arachidonic acid metabolism were also observed. In brief, findings from this exploratory study offered a new insight on the roles of various bioactive lipid molecules in the development of coronary artery disease biomarkers. © 2013 Elsevier Inc.
Source Title: Prostaglandins and Other Lipid Mediators
URI: http://scholarbank.nus.edu.sg/handle/10635/108924
ISSN: 10988823
DOI: 10.1016/j.prostaglandins.2013.08.003
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

10
checked on May 25, 2018

WEB OF SCIENCETM
Citations

10
checked on May 9, 2018

Page view(s)

36
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.