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|Title:||Coffee intake and gastric cancer risk: The Singapore Chinese health study|
|Citation:||Ainslie-Waldman, C.E., Koh, W.-P., Jin, A., Yeoh, K.G., Zhu, F., Wang, R., Yuan, J.-M., Butler, L.M. (2014). Coffee intake and gastric cancer risk: The Singapore Chinese health study. Cancer Epidemiology Biomarkers and Prevention 23 (4) : 638-647. ScholarBank@NUS Repository. https://doi.org/10.1158/1055-9965.EPI-13-0886|
|Abstract:||Background: Despite experimental evidence showing chemopreventive effects of coffee-related compounds on gastric carcinogenesis, epidemiologic studies generally do not support coffee-gastric cancer associations. Observational data are lacking among high-risk populations with sufficient regular coffee consumption. Methods: We examined the association between caffeinated coffee intake and gastric cancer risk in a population-based cohort that enrolled 63,257 Chinese men and women ages 45 to 74 years between 1993 and 1998 in Singapore. Incident gastric cancer cases (n = 647) were identified after a mean follow-up of 14.7 years. Biomarkers of Helicobacter pylori (H. pylori) infection were measured in a subset of gastric cancer cases with blood collected before cancer diagnosis and their matched controls. Results: In the total cohort, daily versus nondaily coffee intake was associated with a statistically nonsignificant decrease in gastric cancer risk [HR = 0.85; 95% confidence interval (CI), 0.69-1.04]. In women, the inverse association strengthened and reached statistical significance (HR = 0.63; 95% CI, 0.46-0.87). In analyses restricted to never smokers and nondrinkers of alcohol, inverse associations strengthened in the total cohort (HR = 0.69; 95% CI, 0.52-0.91) and in women (HR = 0.52; 95% CI, 0.37-0.74). There was no coffee-gastric cancer risk association among men, regardless of smoking status or alcohol consumption. Similar results were observed in the nested case-control study after adjustment for H. pylori infection. Conclusion: Daily coffee consumption may reduce the risk of gastric cancer in high-risk populations, especially among women. Impact: Research aimed at identifying the compounds in coffee that may protect against gastric carcinogenesis is warranted. © 2014 AACR.|
|Source Title:||Cancer Epidemiology Biomarkers and Prevention|
|Appears in Collections:||Staff Publications|
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