Please use this identifier to cite or link to this item:
|Title:||An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity|
|Keywords:||Acute kidney injury|
|Citation:||Chai, L.Y.A., Netea, M.G., Tai, B.C., Khin, L.W., Vonk, A.G., Teo, B.W., Schlamm, H.T., Herbrecht, R., Donnelly, J.P., Troke, P.F., Kullberg, B.-J. (2013). An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity. Journal of Antimicrobial Chemotherapy 68 (7) : 1655-1659. ScholarBank@NUS Repository. https://doi.org/10.1093/jac/dkt055|
|Abstract:||Objectives: The underlying mechanism for amphotericin B-induced acute kidney injury (AKI) remains poorly understood and may be immunologically mediated. We assessed whether the development of nephrotoxicity is linked to a distinct cytokine profile in patients receiving amphotericin B deoxycholate (AmBD). Patients and methods: In 58 patients who received AmBD, circulating serum interleukin (IL)-6, IL-8 and IL-10 were measured at baseline, week 1 and week 2 of antifungal treatment and correlated to the development of renal impairment. The Cox proportional hazards model approach was adopted for analysis. Results: The P value was 0.026 for the overall effect of IL-6 on time to development of AKI. An increasing or nonreceding IL-6 trend by week 1 of AmBD treatment (followed by a decreasing or non-receding IL-6 trend fromweek 1 to week 2) correlated with an increased likelihood of nephrotoxicity [hazard ratio (HR) 6.93, P value 0.005 and HR 3.46, P value 0.035, respectively]. Similarly, persistently increasing IL-8 levels were linked to a 3.84-fold increased likelihood of AKI. Conclusions: In patients receiving AmBD, persistence of an elevated pro-inflammatory cytokine milieu is associated with a predisposition to drug-related kidney injury. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.|
|Source Title:||Journal of Antimicrobial Chemotherapy|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 22, 2019
WEB OF SCIENCETM
checked on Feb 5, 2019
checked on Feb 1, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.