Please use this identifier to cite or link to this item:
|Title:||Adiponectin profile in asian patients undergoing coronary revascularization and its association with plaque vulnerability: IDEAS-ADIPO study|
|Citation:||Lee, C.-H., Hau, W.K.T., Tai, B.-C., Chan, M.Y., Saw, B., Phua, Q.-H., Low, A.F., Yeo, T.-C., Richards, A.M., Tan, H.-C. (2012-12). Adiponectin profile in asian patients undergoing coronary revascularization and its association with plaque vulnerability: IDEAS-ADIPO study. Obesity 20 (12) : 2451-2457. ScholarBank@NUS Repository. https://doi.org/10.1038/oby.2012.92|
|Abstract:||Despite potent insulin-sensitizing, anti-inflammatory, and antiatherogenic effects in animal studies, the relationship between serum adiponectin level and coronary artery disease in patients remains unclear. We determined the adiponectin profile in a cohort of multiethnic Asian patients with coronary artery disease, and the association between serum adiponectin level and culprit lesion necrotic core (NC) content. Ninety-four Asian patients (BMI, 25.3 ± 3.7 kg/m 2) undergoing percutaneous coronary intervention were recruited. The serum adiponectin level was measured (n = 94), and the baseline virtual histology intravascular ultrasound examination was analyzed (n = 88). The median level of adiponectin was 3.7g/ml (interquartile range, 2.8-4.5g/ml). The serum adiponectin level was below 10g/ml in 90 patients (95.7%) and below 6g/ml in 80 patients (85.1%). There was a significant association between ethnicity and serum adiponectin level (P = 0.048). The median adiponectin level was highest among the Chinese, followed by the Malay and the Indians. Serum adiponectin levels were positively associated with culprit lesion NC content. A 1-g/ml increase in log adiponectin was associated with a 3.04% (95% confidence interval: 0.33-5.44) increase in culprit lesion NC content. This association remains significant after adjusting for age, sex, ethnicity, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and procedural indication. We found a low serum level of adiponectin in Asian patients and a significant ethnic effect on serum adiponectin level. Increased serum adiponectin levels were independently associated with increased culprit lesion NC burden, suggesting a role for adiponectin in modulating coronary plaque vulnerability. © 2012 The Obesity Society.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 21, 2019
WEB OF SCIENCETM
checked on Jan 21, 2019
checked on Dec 28, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.