Please use this identifier to cite or link to this item:
|Title:||The Evi5 family in cellular physiology and pathology|
|Source:||Lim, Y.S., Tang, B.L. (2013-06-19). The Evi5 family in cellular physiology and pathology. FEBS Letters 587 (12) : 1703-1710. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2013.04.036|
|Abstract:||The Ecotropic viral integration site 5 (Evi5) and Evi5-like (Evi5L) belong to a small subfamily of the Tre-2/Bub2/Cdc16 (TBC) domain-containing proteins with enigmatically divergent roles as modulators of cell cycle progression, cytokinesis, and cellular membrane traffic. First recognized as a potential oncogene and a cell cycle regulator, Evi5 acts as a GTPase Activating Protein (GAP) for Rab11 in cytokinesis. On the other hand, its homologue Evi5L has Rab-GAP activity towards Rab10 as well as Rab23, and has been implicated in primary cilia formation. Recent genetic susceptibility analysis points to Evi5 as an important factor in susceptibility to multiple sclerosis. We discuss below the myriad of cellular functions exhibited by the Evi5 family members, and their associations with disease conditions. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 27, 2018
WEB OF SCIENCETM
checked on Feb 14, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.