Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2013.04.036
Title: The Evi5 family in cellular physiology and pathology
Authors: Lim, Y.S.
Tang, B.L. 
Keywords: Activating
Cell cycle
Evi5 GTPase
Protein (GAP)
Rab
Issue Date: 19-Jun-2013
Citation: Lim, Y.S., Tang, B.L. (2013-06-19). The Evi5 family in cellular physiology and pathology. FEBS Letters 587 (12) : 1703-1710. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2013.04.036
Abstract: The Ecotropic viral integration site 5 (Evi5) and Evi5-like (Evi5L) belong to a small subfamily of the Tre-2/Bub2/Cdc16 (TBC) domain-containing proteins with enigmatically divergent roles as modulators of cell cycle progression, cytokinesis, and cellular membrane traffic. First recognized as a potential oncogene and a cell cycle regulator, Evi5 acts as a GTPase Activating Protein (GAP) for Rab11 in cytokinesis. On the other hand, its homologue Evi5L has Rab-GAP activity towards Rab10 as well as Rab23, and has been implicated in primary cilia formation. Recent genetic susceptibility analysis points to Evi5 as an important factor in susceptibility to multiple sclerosis. We discuss below the myriad of cellular functions exhibited by the Evi5 family members, and their associations with disease conditions. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/108695
ISSN: 00145793
DOI: 10.1016/j.febslet.2013.04.036
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