Please use this identifier to cite or link to this item: https://doi.org/10.1101/gad.1865310
Title: Structural basis of YAP recognition by TEAD4 in the Hippo pathway
Authors: Chen, L.
Chan, S.W.
Zhang, X.
Walsh, M.
Lim, C.J.
Hong, W. 
Song, H.
Keywords: Hippo signaling pathway
Organ size control
TEAD
YAP
Issue Date: 1-Feb-2010
Source: Chen, L., Chan, S.W., Zhang, X., Walsh, M., Lim, C.J., Hong, W., Song, H. (2010-02-01). Structural basis of YAP recognition by TEAD4 in the Hippo pathway. Genes and Development 24 (3) : 290-300. ScholarBank@NUS Repository. https://doi.org/10.1101/gad.1865310
Abstract: The Hippo signaling pathway controls cell growth, proliferation, and apoptosis by regulating the expression of target genes that execute these processes. Acting downstream from this pathway is the YAP transcriptional coactivator, whose biological function is mediated by the conserved TEAD family transcription factors. The interaction of YAP with TEADs is critical to regulate Hippo pathway-responsive genes. Here, we describe the crystal structure of the YAP-interacting C-terminal domain of TEAD4 in complex with the TEAD-interacting N-terminal domain of YAP. The structure reveals that the N-terminal region of YAP is folded into two short helices with an extended loop containing the PXXΦP motif in between, while the C-terminal domain of TEAD4 has an immunoglobulin-like fold. YAP interacts with TEAD4 mainly through the two short helices. Point mutations of TEAD4 indicate that the residues important for YAP interaction are required for its transforming activity. Mutagenesis reveals that the PXXΦP motif of YAP, although making few contacts with TEAD4, is important for TEAD4 interaction as well as for the transforming activity. © 2010 by Cold Spring Harbor Laboratory Press.
Source Title: Genes and Development
URI: http://scholarbank.nus.edu.sg/handle/10635/108556
ISSN: 08909369
DOI: 10.1101/gad.1865310
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