Please use this identifier to cite or link to this item: https://doi.org/10.1161/HYPERTENSIONAHA.107.101584
Title: Low birthweight is associated with narrower arterioles in adults
Authors: Liew, G.
Wang, J.J.
Duncan, B.B.
Klein, R.
Sharrett, A.R.
Brancati, F.
Yeh, H.-C.
Mitchell, P.
Wong, T.Y. 
Keywords: Barker hypothesis
Birthweight
Developmental origins hypothesis
Hypertension
Issue Date: Apr-2008
Citation: Liew, G., Wang, J.J., Duncan, B.B., Klein, R., Sharrett, A.R., Brancati, F., Yeh, H.-C., Mitchell, P., Wong, T.Y. (2008-04). Low birthweight is associated with narrower arterioles in adults. Hypertension 51 (4) : 933-938. ScholarBank@NUS Repository. https://doi.org/10.1161/HYPERTENSIONAHA.107.101584
Abstract: Low birthweight is associated with increased risk of hypertension, but underlying mechanisms are obscure. We hypothesized structural microvascular alterations may be one such mechanism. We examined the association of birthweight and retinal arteriolar caliber in 3800 persons aged 51 to 72 years participating in a population-based study in 4 US communities (the Atherosclerosis Risk in Communities study). Participants reported full-term birth and their birthweight and had retinal photography. Retinal arteriolar and venular calibers were measured from digitized retinal photographs using a validated computer-assisted method. Lower birthweight was associated with narrower retinal arteriolar caliber, with each kg lower birthweight associated with 2.4 μm (95% confidence intervals, 1.3 to 3.5, P
Source Title: Hypertension
URI: http://scholarbank.nus.edu.sg/handle/10635/108454
ISSN: 0194911X
DOI: 10.1161/HYPERTENSIONAHA.107.101584
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