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|Title:||Low birthweight is associated with narrower arterioles in adults|
Developmental origins hypothesis
|Citation:||Liew, G., Wang, J.J., Duncan, B.B., Klein, R., Sharrett, A.R., Brancati, F., Yeh, H.-C., Mitchell, P., Wong, T.Y. (2008-04). Low birthweight is associated with narrower arterioles in adults. Hypertension 51 (4) : 933-938. ScholarBank@NUS Repository. https://doi.org/10.1161/HYPERTENSIONAHA.107.101584|
|Abstract:||Low birthweight is associated with increased risk of hypertension, but underlying mechanisms are obscure. We hypothesized structural microvascular alterations may be one such mechanism. We examined the association of birthweight and retinal arteriolar caliber in 3800 persons aged 51 to 72 years participating in a population-based study in 4 US communities (the Atherosclerosis Risk in Communities study). Participants reported full-term birth and their birthweight and had retinal photography. Retinal arteriolar and venular calibers were measured from digitized retinal photographs using a validated computer-assisted method. Lower birthweight was associated with narrower retinal arteriolar caliber, with each kg lower birthweight associated with 2.4 μm (95% confidence intervals, 1.3 to 3.5, P|
|Appears in Collections:||Staff Publications|
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