Please use this identifier to cite or link to this item:
|Title:||Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy|
|Citation:||Zhang, F., Liu, H., Chen, S., Low, H., Sun, L., Cui, Y., Chu, T., Li, Y., Fu, X., Yu, Y., Yu, G., Shi, B., Tian, H., Liu, D., Yu, X., Li, J., Lu, N., Bao, F., Yuan, C., Liu, J., Liu, H., Zhang, L., Sun, Y., Chen, M., Yang, Q., Yang, H., Yang, R., Zhang, L., Wang, Q., Zuo, F., Zhang, H., Khor, C.C., Hibberd, M.L., Yang, S., Liu, J., Zhang, X. (2011-12). Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nature Genetics 43 (12) : 1247-1251. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.973|
|Abstract:||We performed a genome-wide association study with 706 individuals with leprosy and 5,581 control individuals and replicated the top 24 SNPs in three independent replication samples, including a total of 3,301 individuals with leprosy and 5,299 control individuals from China. Two loci not previously associated with the disease were identified with genome-wide significance: rs2275606 (combined P = 3.94 × 10 -14, OR = 1.30) on 6q24.3 and rs3762318 (combined P = 3.27 × 10 -11, OR = 0.69) on 1p31.3. These associations implicate IL23R and RAB32 as new susceptibility genes for leprosy. Furthermore, we identified evidence of interaction between the NOD2 and RIPK2 loci, which is consistent with the biological association of the proteins encoded by these genes (NOD2-RIPK2 complex) in activating the NF-κB pathway as a part of the host defense response to infection. Our findings have expanded the biological functions of IL23R by uncovering its involvement in infectious disease susceptibility and suggest a potential involvement of autophagocytosis in leprosy pathogenesis. The IL23R association supports previous observations of the marked overlap of susceptibility genes for leprosy and Crohn's disease, implying common pathogenesis mechanisms. © 2011 Nature America, Inc. All rights reserved.|
|Source Title:||Nature Genetics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 18, 2018
WEB OF SCIENCETM
checked on Sep 3, 2018
checked on Jun 29, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.