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https://doi.org/10.2337/db06-0496
Title: | A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus | Authors: | Ng, D.P.K. Placha, G. Choo, S. Chia, K.-S. Warram, J.H. Krolewski, A.S. |
Keywords: | ACR, albumin-to-creatinine ratio CRF, chronic renal failure ESRD, end-stage renal disease Ins/Del, insertion/deletion MAF, minor allele frequency |
Issue Date: | Sep-2006 | Citation: | Ng, D.P.K., Placha, G., Choo, S., Chia, K.-S., Warram, J.H., Krolewski, A.S. (2006-09). A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Diabetes 55 (9) : 2660-2663. ScholarBank@NUS Repository. https://doi.org/10.2337/db06-0496 | Abstract: | Previous investigations of the ACE gene as a susceptibility factor for diabetic nephropathy have primarily focused on its insertion/deletion (Ins/Del) polymorphism. In a departure from these earlier studies, we used three tagging markers (A-5466C, T-3892C, and Ins/Del) at the ACE locus to test for disease haplotype associations. A case-control study design was used where case subjects were type 2 diabetic patients with advanced diabetic nephropathy, as indicated by the presence of proteinuria or chronic renal failure/end-stage renal disease, while control subjects were normoalbuminuric, despite >6 years of diabetes. None of the individual markers showed significant disease association when considered on their own. However, haplotype analyses revealed a near doubling in the prevalence of the A.T.D risk haplotype in case subjects (0.136) compared with control subjects (0.075) (P = 0.009), thus providing first evidence for a disease haplotype for advanced diabetic nephropathy at the ACE locus. © 2006 by the American Diabetes Association. | Source Title: | Diabetes | URI: | http://scholarbank.nus.edu.sg/handle/10635/108228 | ISSN: | 00121797 | DOI: | 10.2337/db06-0496 |
Appears in Collections: | Staff Publications |
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