Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/108157
Title: Apoptosis versus necrosis in acute pancreatitis
Authors: Bhatia, M. 
Keywords: Acute pancreatitis
Pancreatic acinar cells
Issue Date: Feb-2004
Source: Bhatia, M. (2004-02). Apoptosis versus necrosis in acute pancreatitis. American Journal of Physiology - Gastrointestinal and Liver Physiology 286 (2 49-2) : G189-G196. ScholarBank@NUS Repository.
Abstract: Acute pancreatitis is a disease of variable severity in which some patients experience mild, self-limited attacks, whereas others manifest a severe, highly morbid, and frequently lethal attack. The events that regulate the severity of acute pancreatitis are, for the most part, unknown. It is generally believed that the earliest events in acute pancreatitis occur within acinar cells and result in acinar cell injury. Other processes, such as recruitment of inflammatory cells and generation of inflammatory mediators, are believed to occur subsequent to acinar cell injury, and these "downstream" events are believed to influence the severity of the disease. Several recently reported studies, however, have suggested that the acinar cell response to injury may, itself, be an important determinant of disease severity. In these studies, mild acute pancreatitis was found to be associated with extensive apoptotic acinar cell death, whereas severe acute pancreatitis was found to involve extensive acinar cell necrosis but very little acinar cell apoptosis. These observations led to the hypothesis that apoptosis could be a favorable response to acinar cells and that interventions that favor induction of apoptotic, as opposed to necrotic, acinar cell death might reduce the severity of an attack of acute pancreatitis. Indeed, in an experimental setting, the induction of pancreatic acinar cell apoptosis protects mice against acute pancreatitis. Little is known about the mechanism of apoptosis in the pancreatic acinar cell, although some early attempts have been made in that direction. Also, clinical relevance of these experimental studies remains to be investigated.
Source Title: American Journal of Physiology - Gastrointestinal and Liver Physiology
URI: http://scholarbank.nus.edu.sg/handle/10635/108157
ISSN: 01931857
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

46
checked on Jan 19, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.