Please use this identifier to cite or link to this item:
|Title:||Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder|
|Authors:||Lim, L.C.C. |
|Citation:||Lim, L.C.C., Powell, J., Sham, P., Castle, D., Hunt, N., Murray, R., Gill, M. (1995). Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder. American Journal of Medical Genetics - Neuropsychiatric Genetics 60 (4) : 325-331. ScholarBank@NUS Repository. https://doi.org/10.1002/ajmg.1320600413|
|Abstract:||We present evidence of a genetic association between bipolar disorder and alleles at 3 monoamine oxidase A (MAOA) markers, but not with alleles of a monoamine oxidase B (MAOB) polymorphism. The 3 MAOA markers, including one associated with low MAOA activity, show strong allelic association with each other but surprisingly not with MAOB. Our results are significant only for females, though the number of males in our sample is too small to draw any definite conclusions. Our data is consistent with recent reports of reduced MAOA activity in patients with abnormal behavioral phenotypes. The strength of the association is weak, but significant, which suggests that alleles at the MAOA locus contribute to susceptibility to bipolar disorder rather than being a major determinant.|
|Source Title:||American Journal of Medical Genetics - Neuropsychiatric Genetics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 13, 2019
WEB OF SCIENCETM
checked on Mar 5, 2019
checked on Mar 1, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.