Please use this identifier to cite or link to this item: https://doi.org/10.1002/ajmg.1320600413
Title: Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder
Authors: Lim, L.C.C. 
Powell, J.
Sham, P.
Castle, D.
Hunt, N.
Murray, R.
Gill, M.
Keywords: affective disorder
association study
chromosome X
manic depression
MAOA gene
MAOB gene
Issue Date: 1995
Source: Lim, L.C.C., Powell, J., Sham, P., Castle, D., Hunt, N., Murray, R., Gill, M. (1995). Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder. American Journal of Medical Genetics - Neuropsychiatric Genetics 60 (4) : 325-331. ScholarBank@NUS Repository. https://doi.org/10.1002/ajmg.1320600413
Abstract: We present evidence of a genetic association between bipolar disorder and alleles at 3 monoamine oxidase A (MAOA) markers, but not with alleles of a monoamine oxidase B (MAOB) polymorphism. The 3 MAOA markers, including one associated with low MAOA activity, show strong allelic association with each other but surprisingly not with MAOB. Our results are significant only for females, though the number of males in our sample is too small to draw any definite conclusions. Our data is consistent with recent reports of reduced MAOA activity in patients with abnormal behavioral phenotypes. The strength of the association is weak, but significant, which suggests that alleles at the MAOA locus contribute to susceptibility to bipolar disorder rather than being a major determinant.
Source Title: American Journal of Medical Genetics - Neuropsychiatric Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/108104
ISSN: 01487299
DOI: 10.1002/ajmg.1320600413
Appears in Collections:Staff Publications

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