Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-2999(02)02123-4
Title: Naltrexone attenuates plasma nitric oxide release following acute heat stress
Authors: Sachidhanandam, S.B.
Low, K.S.Y 
Moochhala, S.M. 
Keywords: Circulatory failure
Hyperthermia
Nitric oxide (NO) synthase
Issue Date: 23-Aug-2002
Citation: Sachidhanandam, S.B., Low, K.S.Y, Moochhala, S.M. (2002-08-23). Naltrexone attenuates plasma nitric oxide release following acute heat stress. European Journal of Pharmacology 450 (2) : 163-167. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-2999(02)02123-4
Abstract: Previous studies have shown that naltrexone attenuates morbidity and mortality in heat stress by inhibiting endogenous opioids. In this study, we hypothesized that naltrexone can decrease heat stress by attenuating nitric oxide release. Male Sprague-Dawley rats were pretreated with naltrexone or normal saline, and exposed to 45°C for 25 min; controls were exposed to 25°C. Colonic temperatures were recorded and plasma samples from an in-dwelling i.v. cannula were analyzed for nitrate/nitrite levels. Following heat stress, peak colonic temperature was significantly diminished (P<0.05) in naltrexone-treated rats compared to saline-treated rats. Plasma nitrate/nitrite levels were significantly lower (P<0.05) in naltrexone-treated rats compared to saline-treated rats. These findings suggest that naltrexone is able to attenuate the rise in plasma nitric oxide levels commonly observed after heat stress. © 2002 Elsevier Science B.V. All rights reserved.
Source Title: European Journal of Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/108071
ISSN: 00142999
DOI: 10.1016/S0014-2999(02)02123-4
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

7
checked on Oct 15, 2018

WEB OF SCIENCETM
Citations

7
checked on Oct 15, 2018

Page view(s)

38
checked on Oct 5, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.