Please use this identifier to cite or link to this item: https://doi.org/10.1248/bpb.26.52
Title: Total coenzyme Q10 concentrations in asian men following multiple oral 50-mg doses administered as coenzyme Q10 sustained release tablets or regular tablets
Authors: Lu, W.-L.
Zhang, Q.
Lee, H.-S. 
Zhou, T.-Y.
Sun, H.-D.
Zhang, D.-W.
Zheng, L.
Lee, M.
Wong, S.-M.
Keywords: Asian human healthy volunteer
Coenzyme Q10
HPLC-UV
Plasma concentration
Sustained release tablets
Issue Date: Jan-2003
Citation: Lu, W.-L., Zhang, Q., Lee, H.-S., Zhou, T.-Y., Sun, H.-D., Zhang, D.-W., Zheng, L., Lee, M., Wong, S.-M. (2003-01). Total coenzyme Q10 concentrations in asian men following multiple oral 50-mg doses administered as coenzyme Q10 sustained release tablets or regular tablets. Biological and Pharmaceutical Bulletin 26 (1) : 52-55. ScholarBank@NUS Repository. https://doi.org/10.1248/bpb.26.52
Abstract: Coenzyme Q10 (CoQ10), a highly lipophilic compound present in the inner mitochondrial membrane, is essential for production of cellular energy in the form of ATP. CoQ10 is used as a dietary supplement and for treatment of various cardiovascular disorders. Our goal was to compare the CoQ10 levels in Asians following multiple oral doses administered as sustained release or regular tablets. Twenty healthy male volunteers (19-23 years old) were divided into two equal groups. Each subject in Group I received 50 mg oral doses of coenzymc Q10 as sustained release tablets once a day for fifteen days, while subject in Group II received 50 mg doses of coenzyme Q10 regular tablets. The CoQ10 levels were measured by HPLC-UV (reverse phase ODS column, 10 μm, 250x4.6 mm; oven temperature 30°C). Mobile phase was constituted by methanol-ethanol 9:1 v/v. Flow rate was 1.5 ml/min and UV detection was carried out at 275 nm. Coenzyme Q9 was used as an internal standard. CoQ10 baseline in the morning was 0.88±0.48mg/l. Following 1 week 50 mg/d dosing of CoQ10, plasma CoQ10 concentrations increased to 1.85±1.03 mg/l for sustained release tablets and up to 1.37±0.74mg/l for regular tablets. The net increment proportion in AUC for sustained release and regular tablets were 148.26±176.56%, 102.57±130.00%. respectively. Both preparations significantly increased the systemic exposure when compared to endogenous baseline.
Source Title: Biological and Pharmaceutical Bulletin
URI: http://scholarbank.nus.edu.sg/handle/10635/108070
ISSN: 09186158
DOI: 10.1248/bpb.26.52
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