Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/108056
Title: Differences in anxiety-related behavior between apolipoprotein E-deficient C57BL/6 and wild type C57BL/6 mice
Authors: McLachlan, C.S. 
Yi Xing Soh, C.
Keywords: Anxiety
Apolipoprotein E
Elevated plus maze
Mice
Issue Date: 2005
Source: McLachlan, C.S.,Yi Xing Soh, C. (2005). Differences in anxiety-related behavior between apolipoprotein E-deficient C57BL/6 and wild type C57BL/6 mice. Physiological Research 54 (6) : 701-704. ScholarBank@NUS Repository.
Abstract: The influence of ApoE gene deletion on the anxiety state has not been previously investigated. The elevated plus maze was used in this study to determine differences in anxiety-related behavior between apoE-deficient and wild type C57BL/6 mice. The apoE-deficient mice demonstrated less anxiety on the elevated plus maze by spending more time in the open arms of the elevated plus maze compared to wild type mice (p<0.001). Additionally, female apoE-deficient mice visited the open arm of the maze more often than their apoE-deficient male counterpart (p<0.05). The anxiety state and/or sex are possible variables to be considered when designing physiological and/or behavioral studies involving mice that are apoE-deficient. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic.
Source Title: Physiological Research
URI: http://scholarbank.nus.edu.sg/handle/10635/108056
ISSN: 08628408
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

25
checked on Dec 7, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.