Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2004.12.030
Title: A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury
Authors: Lau, H.Y.
Wong, F.L. 
Bhatia, M. 
Keywords: Acute pancreatitis
Caerulein
CP-96345
Substance P
Issue Date: 11-Feb-2005
Source: Lau, H.Y.,Wong, F.L.,Bhatia, M. (2005-02-11). A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury. Biochemical and Biophysical Research Communications 327 (2) : 509-515. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2004.12.030
Abstract: Earlier studies have shown that mice deficient in NK1 receptors or its ligand, substance P, are protected against acute pancreatitis and associated lung injury. In the current study, the protective effect of NK1 receptor blockage against acute pancreatitis and associated lung injury was investigated, using a specific receptor antagonist, CP-96345. Acute pancreatitis was induced in mice by intraperitoneal (i.p.) injections of caerulein. Substance P levels in plasma, pancreas, and lungs were found to be elevated in a caerulein dose-dependent manner. Mice treated with CP-96345, either prophylactically, or therapeutically, were protected against acute pancreatitis and associated lung injury as evident by attenuation in plasma amylase, pancreatic and pulmonary myeloperoxidase activities, and histological evidence of pancreatic and pulmonary injuries. Pulmonary microvascular permeability was also reduced as a result of CP-96345 treatment. These results point to a key role of NK1 receptors in acute pancreatitis and associated lung injury. © 2004 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/108055
ISSN: 0006291X
DOI: 10.1016/j.bbrc.2004.12.030
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