Please use this identifier to cite or link to this item: https://doi.org/10.1002/pmic.200401084
Title: Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma
Authors: Luk, J.M.
Su, Y.C.F.
Lam, S.C.T.
Lee, C.K.
Hu, M.Y.
He, Q.Y.
Lau, G.K.
Wong, F.W.S. 
Fan, S.-T.
Keywords: Hepatocellular carcinoma
Ku autoantigen
Monoclonal antibody
Tumor marker
Issue Date: May-2005
Source: Luk, J.M., Su, Y.C.F., Lam, S.C.T., Lee, C.K., Hu, M.Y., He, Q.Y., Lau, G.K., Wong, F.W.S., Fan, S.-T. (2005-05). Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma. Proteomics 5 (7) : 1980-1986. ScholarBank@NUS Repository. https://doi.org/10.1002/pmic.200401084
Abstract: A murine monoclonal antibody (mAb), CLD3 (IgG1,κ), was generated against hepatocellular carcinoma (HCC). Both immunofluorescence and immunohistochemical assays indicated the reactivity of CLD3 mAb localized at the nucleus and/or cytoplasm of tumorigenic HCC cell lines as well as in liver cancer tissues. By immunoprecipitation and using the matrix-assisted laser desorption/ionization-time of flight mass spectrometry approach, the antigenic specificity of CLD3 was determined to be heterodimeric Ku70 and Ku80 autoantigen, which was confirmed by Western blotting. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA.
Source Title: Proteomics
URI: http://scholarbank.nus.edu.sg/handle/10635/108053
ISSN: 16159853
DOI: 10.1002/pmic.200401084
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