Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.onc.1209531
Title: Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration
Authors: Lim, C.P.
Phan, T.-T. 
Lim, I.J. 
Cao, X.
Keywords: Collagen
Fibroblasts
Keloid
Migration
Scar
Stat3
Issue Date: 31-Aug-2006
Source: Lim, C.P., Phan, T.-T., Lim, I.J., Cao, X. (2006-08-31). Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration. Oncogene 25 (39) : 5416-5425. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.onc.1209531
Abstract: Keloids, partially considered as benign tumors, represent the most extreme example of cutaneous scarring that uniquely afflicts humans as a pathological response to wound healing. It is characterized by excessive deposition of collagen and other extracellular matrix components by dermal fibroblasts. Upon cutaneous injury, cocktails of chemokines, cytokines and growth factors are secreted temporally and spatially to direct appropriate responses from neutrophils, macrophages, keratinocytes and fibroblasts to facilitate normal wound healing. Signal transducer and activator of transcription 3 (Stat3) is an oncogene and a latent transcription factor activated by various cytokines and growth factors. We investigated the possible role of Stat3 in keloid scar pathogenesis by examining skin tissue and cultured fibroblasts from keloid-scarred patients. We observed enhanced expression and phosphorylation of Stat3 in keloid scar tissue, and in cultured keloid fibroblasts (KFs) in vitro. Increased activation of Janus kinase (Jak)2, but not Jak1, was detected in KFs, and suppression of Jak2 by its inhibitor repressed Stat3 Y705 phosphorylation. Inhibition of Stat3 expression and phosphorylation by short interfering RNA or Cucurbitacin I resulted in the loss of collagen production, impaired proliferation and delayed cell migration in KFs. We show, for the first time, a role of Stat3 in keloid pathogenesis. Inhibitors of Stat3 may be useful therapeutic strategies for the prospective treatment of keloid scars. © 2006 Nature Publishing Group. All rights reserved.
Source Title: Oncogene
URI: http://scholarbank.nus.edu.sg/handle/10635/107951
ISSN: 09509232
DOI: 10.1038/sj.onc.1209531
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