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|Title:||Effect of ABC transporters on HIV-1 infection: Inhibition of virus production by the MDR1 transporter|
|Authors:||Lee, C.G.L. |
Acquired immunodeficiency syndrome
|Citation:||Lee, C.G.L.,Ramachandra, M.,Jeang, K.-T.,Martin, M.A.,Pastan, I.,Gottesman, M.M. (2000). Effect of ABC transporters on HIV-1 infection: Inhibition of virus production by the MDR1 transporter. FASEB Journal 14 (3) : 516-522. ScholarBank@NUS Repository.|
|Abstract:||The MDR1 multidrug transporter P-gp (P-glycoprotein) is an efflux pump that extrudes diverse hydrophobic drugs and peptides from cells. Since the entry of HIV-1 into cells involves an initial interaction of the viral gp41 hydrophobic peptide with the plasma membrane, a potential effect of P-gp on HIV-1 infectivity was explored. Virus production was greatly decreased when P-gp was overexpressed at the surface of a continuous CD4+ human T-leukemic cell line (12D7) infected with HIV-1(NL4-3), a T-tropic molecular clone of HIV-1. P-gp overexpression did not significantly alter the surface expression or distribution of either the HIV-1 receptor CD4 or the coreceptor CXCR4. Reduction of HIV-1 infectivity in P-gp-expressing cells occurred both during the fusion of viral and plasma membranes and at subsequent step(s) in the HIV-1 life cycle.|
|Source Title:||FASEB Journal|
|Appears in Collections:||Staff Publications|
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