Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/107681
Title: A new pre-S containing recombinant hepatitis B vaccine and its effect on non-responders: A preliminary observation
Authors: Yap, I. 
Chan, S.H. 
Keywords: HLA-typing
non-responder to S-vaccine
pre-S 1
pre-S 2
Issue Date: Jan-1996
Source: Yap, I.,Chan, S.H. (1996-01). A new pre-S containing recombinant hepatitis B vaccine and its effect on non-responders: A preliminary observation. Annals of the Academy of Medicine Singapore 25 (1) : 120-122. ScholarBank@NUS Repository.
Abstract: Nine healthy subjects who had no detectable antibody response when initially vaccinated with hepatitis B vaccine (plasma derived and/or yeast derived) were revaccinated with three 20 μg doses of a new recombinant hepatitis B (HB) vaccine (SCI-B-VAC) derived from Chinese hamster ovary (CHO) cells and consisting of both the major S protein and the minor pre-S (S 1 and S 2) proteins of the viral coat. Seroconversion was successful in 78% of these non-responders after the second dose and just before the third vaccination. The geometric mean titres of the antiHBs were 587 iu/l one month after the course of vaccination. This study, though preliminary, indicated that pre-S containing CHO vaccine is effective in inducing antibody response in S-vaccine non-responders and also suggested that the added pre-S region in HBV vaccine helps antiHBs production. Frequency of HLA B 46 and B 15 were higher in non-responders compared to normal subjects (P = 0.04) supporting the possibility that genetic factors may modulate the immune response to HB vaccination.
Source Title: Annals of the Academy of Medicine Singapore
URI: http://scholarbank.nus.edu.sg/handle/10635/107681
ISSN: 03044602
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

54
checked on Dec 8, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.