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|Title:||A new pre-S containing recombinant hepatitis B vaccine and its effect on non-responders: A preliminary observation|
|Authors:||Yap, I. |
non-responder to S-vaccine
|Source:||Yap, I.,Chan, S.H. (1996-01). A new pre-S containing recombinant hepatitis B vaccine and its effect on non-responders: A preliminary observation. Annals of the Academy of Medicine Singapore 25 (1) : 120-122. ScholarBank@NUS Repository.|
|Abstract:||Nine healthy subjects who had no detectable antibody response when initially vaccinated with hepatitis B vaccine (plasma derived and/or yeast derived) were revaccinated with three 20 μg doses of a new recombinant hepatitis B (HB) vaccine (SCI-B-VAC) derived from Chinese hamster ovary (CHO) cells and consisting of both the major S protein and the minor pre-S (S 1 and S 2) proteins of the viral coat. Seroconversion was successful in 78% of these non-responders after the second dose and just before the third vaccination. The geometric mean titres of the antiHBs were 587 iu/l one month after the course of vaccination. This study, though preliminary, indicated that pre-S containing CHO vaccine is effective in inducing antibody response in S-vaccine non-responders and also suggested that the added pre-S region in HBV vaccine helps antiHBs production. Frequency of HLA B 46 and B 15 were higher in non-responders compared to normal subjects (P = 0.04) supporting the possibility that genetic factors may modulate the immune response to HB vaccination.|
|Source Title:||Annals of the Academy of Medicine Singapore|
|Appears in Collections:||Staff Publications|
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