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|Title:||Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region|
|Citation:||Lu, S.-J.,Day, N.E.,Degos, L.,Lepage, V.,Wang, P.-C.,Chan, S.-H.,Simons, M.,McKnight, B.,Easton, D.,Zeng, Y.,De-Thé, G. (1990-08-02). Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature 346 (6283) : 470-471. ScholarBank@NUS Repository.|
|Abstract:||THE frequency of nasopharyngeal carcinoma is nearly 100-fold higher in southern Chinese than in most European populations 1. Earlier studies have suggested that an increased risk of nasopharyngeal carcinoma is associated with specific haplotypes in the HLA region: relative risks slightly over twofold were found for haplotypes A2, Bw46 and the antigen B17 (refs 2-4). We now report a linkage study based on affected sib pairs which suggests that a gene closely linked to the HLA locus confers a greatly increased risk of nasopharyngeal carcinoma. The maximum likelihood estimate is of a relative risk of approximately 21. The relationship between this suspected disease susceptibility gene (or genes) and known viral and environmental aetiological factors remains to be elucidated.|
|Appears in Collections:||Staff Publications|
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