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Title: HLA association in Singapore children with Grave's disease
Authors: Tan Siok-Hoon
Chan Soh-Ha 
Lee Bee-Wah 
Wee Guan-Bock
Wong Hock-Boon 
Issue Date: 1988
Source: Tan Siok-Hoon,Chan Soh-Ha,Lee Bee-Wah,Wee Guan-Bock,Wong Hock-Boon (1988). HLA association in Singapore children with Grave's disease. Metabolism: Clinical and Experimental 37 (6) : 518-519. ScholarBank@NUS Repository.
Abstract: HLA associations in patients with Grave's disease are B8 in whites and BW35 in Japanese. This study shows the HLA association of Singapore Chinese children with Grave's disease. Forty unrelated Chinese children with Grave's disease were typed. The control population consisted of 238 consecutive unrelated normal Chinese individuals. Patients with Grave's disease showed a significantly higher frequency of BW46 than control subjects (corrected P = .0005, relative risk (RR) = 4.61). Only two patients had BW35 and none had B8. There was an increased frequency of both homozygotes and heterozygotes in thyrotoxic patients compared with controls, the RR being slightly higher in the homozygotes. Among the patients, BW 46 was most frequently associated with B40, B13, and B15. The joint occurrence of BW46/B40 in thyrotoxic children had a lower relative risk than BW46 alone, whereas the joint occurrence of BW46/B13 had a higher relative risk than BW46 alone.
Source Title: Metabolism: Clinical and Experimental
ISSN: 00260495
Appears in Collections:Staff Publications

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