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|Title:||The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells|
|Keywords:||APC Min mice|
T cell transcription factor 4
|Source:||Jansson, E.Å., Are, A., Greicius, G., Kuo, I.-C., Kelly, D., Arulampalam, V., Pettersson, S. (2005-02-01). The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells. Proceedings of the National Academy of Sciences of the United States of America 102 (5) : 1460-1465. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.0405928102|
|Abstract:||Control of colon cell fate in adenocarcinomas is disrupted, in part, due to aberrant Wnt/β-catenin signaling. The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) has been implicated in the development of colon cancers. In the adenomatous polyposis coli multiple intestinal neoplasia (APC Min) mouse cancer model, PPARγ expression in the colonic mucosa is markedly altered. In addition, PPARγ protein levels are elevated, possibly through sequestration by activated β-catenin in colon cancer cell lines. Induction of the Wnt/β-catenin pathway by LiCl also elevated PPARγ levels and induced PPARγ-dependent reporter and endog-enous target genes. Mechanistically, PPARγ, through interactions with β-catenin and T cell transcription factor (Tcf)-4, may be a determinant of cell fate and is likely a target of the Wnt pathway in cancer cells.|
|Source Title:||Proceedings of the National Academy of Sciences of the United States of America|
|Appears in Collections:||Staff Publications|
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