Please use this identifier to cite or link to this item:
|Title:||Synthetic hydrogels for controlled stem cell differentiation|
|Authors:||Liu, S.Q. |
Rachel Ee, P.L.
|Citation:||Liu, S.Q., Tay, R., Khan, M., Rachel Ee, P.L., Hedrick, J.L., Yang, Y.Y. (2009). Synthetic hydrogels for controlled stem cell differentiation. Soft Matter 6 (1) : 67-81. ScholarBank@NUS Repository. https://doi.org/10.1039/b916705f|
|Abstract:||Stem cells offer great promise for regenerative medicine because of their pluripotency and their ability for self-renewal; however, their use in clinical treatments requires knowledge of the cues that control stem cell fate in vivo, and the ability to recapitulate those cues in tissue-engineered systems to direct differentiation into desired cell types and tissues. Hydrogels formed from poly(ethylene glycol) (PEG) are useful as scaffolds for promoting stem cell growth and differentiation towards the formation of tissues. The mechanical and biochemical microenvironment of these PEG hydrogels can be modified in a variety of ways to control cellular functions that are important in determining and maintaining stem cell phenotype. In this review, recent advances in the synthesis and modification of PEG hydrogels will be presented, along with important physicochemical considerations in the design of these hydrogels to better mimic the stem cell microenvironment and direct stem cell differentiation. © The Royal Society of Chemistry 2010.|
|Source Title:||Soft Matter|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 11, 2018
WEB OF SCIENCETM
checked on Jul 25, 2018
checked on Jul 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.