Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.drudis.2006.03.012
Title: Progress and problems in the exploration of therapeutic targets
Authors: Zheng, C. 
Han, L. 
Yap, C.W. 
Xie, B.
Chen, Y. 
Issue Date: May-2006
Source: Zheng, C., Han, L., Yap, C.W., Xie, B., Chen, Y. (2006-05). Progress and problems in the exploration of therapeutic targets. Drug Discovery Today 11 (9-10) : 412-420. ScholarBank@NUS Repository. https://doi.org/10.1016/j.drudis.2006.03.012
Abstract: Drugs exert their therapeutic effect by binding and regulating the activity of a particular protein or nucleic acid target. A large number of targets have been explored for drug discovery. Continuous effort has been directed at the search for new targets and more-extensive exploration of existing targets. Knowledge of these targets facilitates the understanding of molecular mechanisms of drugs and the effort required for drug discovery and target searches. Areas of progress, current focuses of research and development and the difficulties in target exploration are reviewed. The characteristics of the currently explored targets and their correlation to the level of difficulty for target exploration are analyzed. From these characteristics, simple rules can be derived for estimating the difficulty level of target exploration. The feasibility of predicting druggable proteins by using simple rules and sequence-derived physicochemical properties is also discussed. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Drug Discovery Today
URI: http://scholarbank.nus.edu.sg/handle/10635/106699
ISSN: 13596446
DOI: 10.1016/j.drudis.2006.03.012
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

48
checked on Jan 17, 2018

WEB OF SCIENCETM
Citations

43
checked on Nov 16, 2017

Page view(s)

21
checked on Jan 14, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.