Please use this identifier to cite or link to this item:
|Title:||Multidrug resistance proteins (MRPs) and implication in drug development|
|Authors:||Tian, Q. |
|Citation:||Tian, Q., Zhang, J., Chan, E., Duan, W., Zhou, S. (2005-01). Multidrug resistance proteins (MRPs) and implication in drug development. Drug Development Research 64 (1) : 1-18. ScholarBank@NUS Repository. https://doi.org/10.1002/ddr.10427|
|Abstract:||The multidrug resistance protein (MRP)-related ABCC family (MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8, and MRP9) belongs to the ATP-binding cassette (ABC) superfamily of transport proteins. They are capable of transporting a structurally diverse array of endo- and xenobiotics and their metabolites across cell membranes. These transporters play an important role in the absorption, disposition, and elimination of these compounds in the body. In particular, increased expression of these drug transporters in tumor cells is associated with resistance to a number of important chemotherapeutic agents. This review highlights the biochemical and pharmacological properties of MRP1-9 and their implications in drug development. A detailed study on the biochemical function and regulation of MRPs is important in drug development, as this may help to avoid drug toxicity, drug resistance, and drug-drug interactions and to optimize cancer chemotherapy. © 2005 Wiley-Liss, Inc.|
|Source Title:||Drug Development Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 11, 2018
WEB OF SCIENCETM
checked on Oct 23, 2018
checked on Nov 9, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.