Please use this identifier to cite or link to this item: https://doi.org/10.1517/17425240903468696
Title: Integrin targeted drug and gene delivery
Authors: Wang, Z.
Chui, W.-K. 
Ho, P.C. 
Keywords: Angiogenesis
Antagonist
Conjugation
Drug delivery
Integrin targeting
Issue Date: Feb-2010
Citation: Wang, Z., Chui, W.-K., Ho, P.C. (2010-02). Integrin targeted drug and gene delivery. Expert Opinion on Drug Delivery 7 (2) : 159-171. ScholarBank@NUS Repository. https://doi.org/10.1517/17425240903468696
Abstract: Importance of the field: Recently, there has been substantial progress in the development of integrin targeted pharmaceuticals and drug delivery systems. Integrin is an important member in the cell adhesion molecule family, which is involved in regulation of complex biological conditions, from keeping normal physiological activities to causing cellular dysfunction in diseased cells. Hence, it is timely to summarize the recent developments in integrin targeted drug and gene delivery systems to understand better their advantages and limitations. Areas covered in this review: In this review, advances in the discovery and clinical trials of these integrin antagonists against different integrin subunits are summarized and discussed. Besides using integrin inhibitor as a single therapeutic agent, integrin antagonists that were conjugated to cytotoxic drugs by synthetic chemistry or coupled to biomacromolecules by either DNA recombination technology or fusion protein technology for integrin targeted therapy have been explored. Furthermore, nanoparticles with integrin targeting ligands for both drug and gene delivery, typically for antiangiogenesis and anticancer therapy, are highlighted and evaluated. What the reader will gain: This review sheds light on the future development of integrin targeted drug and/or gene delivery systems. Take home message: Although thus far there are still limitations, integrin targeted delivery systems have already shown their potential as important pharmaceuticals in the near future. © 2010 Informa UK Ltd.
Source Title: Expert Opinion on Drug Delivery
URI: http://scholarbank.nus.edu.sg/handle/10635/106668
ISSN: 17425247
DOI: 10.1517/17425240903468696
Appears in Collections:Staff Publications

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