Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jchromb.2008.04.033
Title: Gas chromatography/mass spectrometry in metabolic profiling of biological fluids
Authors: Pasikanti, K.K.
Ho, P.C. 
Chan, E.C.Y. 
Keywords: Blood
Gas chromatography
GC/MS
Metabolic profiling
Metabolomics
Metabonomics
Urine
Issue Date: 15-Aug-2008
Citation: Pasikanti, K.K., Ho, P.C., Chan, E.C.Y. (2008-08-15). Gas chromatography/mass spectrometry in metabolic profiling of biological fluids. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 871 (2) : 202-211. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jchromb.2008.04.033
Abstract: One of the objectives of metabonomics is to identify subtle changes in metabolite profiles between biological systems of different physiological or pathological states. Gas chromatography mass spectrometry (GC/MS) is a widely used analytical tool for metabolic profiling in various biofluids, such as urine and blood due to its high sensitivity, peak resolution and reproducibility. The availability of the GC/MS electron impact (EI) spectral library further facilitates the identification of diagnostic biomarkers and aids the subsequent mechanistic elucidation of the biological or pathological variations. With the advent of new comprehensive two dimensional GC (GC × GC) coupled to time-of-flight mass spectrometry (TOFMS), it is possible to detect more than 1200 compounds in a single analytical run. In this review, we discuss the applications of GC/MS in the metabolic profiling of urine and blood, and discuss its advances in methodologies and technologies. © 2008.
Source Title: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/106655
ISSN: 15700232
DOI: 10.1016/j.jchromb.2008.04.033
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