Please use this identifier to cite or link to this item: https://doi.org/10.1117/12.890850
Title: Nano-sensitizers for multi-modality optical diagnostic imaging and therapy of cancer
Authors: Olivo, M. 
Lucky, S.S.
Bhuvaneswari, R.
Dendukuri, N.
Keywords: EGFR
Gold nanoparticle
Hypericin
Nanosensitiser
Optical coherence tomography
Optical probes
Surface enhanced Raman scattering
Issue Date: 2011
Citation: Olivo, M., Lucky, S.S., Bhuvaneswari, R., Dendukuri, N. (2011). Nano-sensitizers for multi-modality optical diagnostic imaging and therapy of cancer. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8087 : -. ScholarBank@NUS Repository. https://doi.org/10.1117/12.890850
Abstract: We report novel bioconjugated nanosensitizers as optical and therapeutic probes for the detection, monitoring and treatment of cancer. These nanosensitisers, consisting of hypericin loaded bioconjugated gold nanoparticles, can act as tumor cell specific therapeutic photosensitizers for photodynamic therapy coupled with additional photothermal effects rendered by plasmonic heating effects of gold nanoparticles. In addition to the therapeutic effects, the nanosensitizer can be developed as optical probes for state-of-the-art multi-modality in-vivo optical imaging technology such as in-vivo 3D confocal fluorescence endomicroscopic imaging, optical coherence tomography (OCT) with improved optical contrast using nano-gold and Surface Enhanced Raman Scattering (SERS) based imaging and bio-sensing. These techniques can be used in tandem or independently as in-vivo optical biopsy techniques to specifically detect and monitor specific cancer cells in-vivo. Such novel nanosensitizer based optical biopsy imaging technique has the potential to provide an alternative to tissue biopsy and will enable clinicians to make real-time diagnosis, determine surgical margins during operative procedures and perform targeted treatment of cancers. © 2011 SPIE-OSA.
Source Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
URI: http://scholarbank.nus.edu.sg/handle/10635/106535
ISBN: 9780819486844
ISSN: 16057422
DOI: 10.1117/12.890850
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