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Title: Use of a passive equilibration methodology to encapsulate cisplatin into preformed thermosensitive liposomes
Authors: Woo, J.
Chiu, G.N.C. 
Karlsson, G.
Wasan, E.
Ickenstein, L.
Edwards, K.
Bally, M.B.
Keywords: Cisplatin
Drug release
Passive equilibration
Thermosensitive liposomes
Issue Date: 12-Feb-2008
Citation: Woo, J., Chiu, G.N.C., Karlsson, G., Wasan, E., Ickenstein, L., Edwards, K., Bally, M.B. (2008-02-12). Use of a passive equilibration methodology to encapsulate cisplatin into preformed thermosensitive liposomes. International Journal of Pharmaceutics 349 (1-2) : 38-46. ScholarBank@NUS Repository.
Abstract: A conventional, cholesterol-containing liposome formulation of cisplatin has demonstrated insignificant activity in clinical trials, due in part, to insufficient release of encapsulated content following localization within solid tumors. For this reason, the development of a triggered release liposome formulation is desirable. In this report, cisplatin was encapsulated into lysolipid-containing thermosensitive liposomes (LTSL) using a novel technique, which relies on the equilibration of cisplatin across the liposomal membrane at temperatures above the gel-to-liquid crystalline phase transition temperature (TC) of the bulk phospholipid. Mild heating and drug loading into LTSL did not induce morphological changes of the liposomes. In vitro data demonstrated that >95% of encapsulated cisplatin was released from LTSL within 5 min following mild heating at 42 °C, while
Source Title: International Journal of Pharmaceutics
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2007.07.020
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