Please use this identifier to cite or link to this item: https://doi.org/10.1039/c4ob00095a
Title: Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity
Authors: Tan, S.W.B.
Chai, C.L.L. 
Moloney, M.G.
Issue Date: 21-Mar-2014
Citation: Tan, S.W.B., Chai, C.L.L., Moloney, M.G. (2014-03-21). Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity. Organic and Biomolecular Chemistry 12 (11) : 1711-1716. ScholarBank@NUS Repository. https://doi.org/10.1039/c4ob00095a
Abstract: An efficient approach for the introduction of 3-acyl side chain groups onto a core tetramate system, which are suitable for further manipulation by nucleophilic displacement or Horner-Wadsworth-Emmons coupling, provides access to a diverse library of substituted tetramates related to two distinct classes of natural products, equisetin and pramanicin. Assessment against S. aureus and E. coli indicated that some compounds exhibit significant antibacterial activity, providing unusual leads for further optimisation in the drug discovery process. © 2014 The Royal Society of Chemistry.
Source Title: Organic and Biomolecular Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/106402
ISSN: 14770520
DOI: 10.1039/c4ob00095a
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

3
checked on Jun 22, 2018

WEB OF SCIENCETM
Citations

2
checked on May 15, 2018

Page view(s)

44
checked on May 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.