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|Title:||Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity|
|Citation:||Tan, S.W.B., Chai, C.L.L., Moloney, M.G. (2014-03-21). Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity. Organic and Biomolecular Chemistry 12 (11) : 1711-1716. ScholarBank@NUS Repository. https://doi.org/10.1039/c4ob00095a|
|Abstract:||An efficient approach for the introduction of 3-acyl side chain groups onto a core tetramate system, which are suitable for further manipulation by nucleophilic displacement or Horner-Wadsworth-Emmons coupling, provides access to a diverse library of substituted tetramates related to two distinct classes of natural products, equisetin and pramanicin. Assessment against S. aureus and E. coli indicated that some compounds exhibit significant antibacterial activity, providing unusual leads for further optimisation in the drug discovery process. © 2014 The Royal Society of Chemistry.|
|Source Title:||Organic and Biomolecular Chemistry|
|Appears in Collections:||Staff Publications|
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