Synthesis and hererocyclizations of 3,4-dihydroquinazolin-2-yl guanidine in the search of new anticancer agents

Please use this identifier to cite or link to this item: https://doi.org/10.3987/COM-09-11672

Title:	Synthesis and hererocyclizations of 3,4-dihydroquinazolin-2-yl guanidine in the search of new anticancer agents
Authors:	Dolzhenko, A.V. Foo, M.C. Tan, B.J. Dolzhenko, A.V. Chiu, G.N.C. Chui, W.K.
Keywords:	Anticancer Activity Fused 1,3,5-Triazine Heterylguanidine Hindered Rotation Quinazoline
Issue Date:	1-Jul-2009
Citation:	Dolzhenko, A.V., Foo, M.C., Tan, B.J., Dolzhenko, A.V., Chiu, G.N.C., Chui, W.K. (2009-07-01). Synthesis and hererocyclizations of 3,4-dihydroquinazolin-2-yl guanidine in the search of new anticancer agents. Heterocycles 78 (7) : 1761-1775. ScholarBank@NUS Repository. https://doi.org/10.3987/COM-09-11672
Abstract:	The cyclocondensations of 3,4-dihydroquinazolin-2-yl guanidine with a variety of electrophilic reagents viz. aldehydes, ketones, triethyl orthoformate, diethyl ethoxymethylenemalonate, carbon disulfide and trichloroacetonitrile were found to afford l,3,5-triazino[2,l-b]quinazolin.However, some unexpected reactions were also observed. The structural properties such as tautomerism and hinderance to conformational rotation were also investigated. The results of biological testing suggested that the l,3,5-triazino[2,l-b]quinazolinenucleus could be a new promising scaffold for the development of potential anticancer agents. © 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved.
Source Title:	Heterocycles
URI:	http://scholarbank.nus.edu.sg/handle/10635/106393
ISSN:	03855414
DOI:	10.3987/COM-09-11672
Appears in Collections:	Staff Publications

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