Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2- amines

Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11094-007-0103-5

Title:	Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2- amines
Authors:	Dolzhenko, A.V. Chui, W.K.
Issue Date:	Sep-2007
Citation:	Dolzhenko, A.V.,Chui, W.K. (2007-09). Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2- amines. Pharmaceutical Chemistry Journal 41 (9) : 470-473. ScholarBank@NUS Repository. https://doi.org/10.1007/s11094-007-0103-5
Abstract:	Several 4-substituted 1,3,5-triazino[1,2-a]benzimidazol-2-amines were prepared via cyclization of 2-benzimidazolylguanidine with various reactants. The prototropic tautomerism in the obtained dihydro analogs was investigated. According to the NMR data, the 3,4-dihydro form was found to predominate in DMSO solutions. All tested compounds inhibited the activity of mammalian dihydrofolate reductase. The most active compound was 4,4-dimethyl-3,4- dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine (IC50 = 10.9 mM). © 2007 Springer Science+Business Media, Inc.
Source Title:	Pharmaceutical Chemistry Journal
URI:	http://scholarbank.nus.edu.sg/handle/10635/106388
ISSN:	0091150X
DOI:	10.1007/s11094-007-0103-5
Appears in Collections:	Staff Publications

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