Please use this identifier to cite or link to this item:
|Title:||Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2- amines|
|Authors:||Dolzhenko, A.V. |
|Citation:||Dolzhenko, A.V.,Chui, W.K. (2007-09). Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2- amines. Pharmaceutical Chemistry Journal 41 (9) : 470-473. ScholarBank@NUS Repository. https://doi.org/10.1007/s11094-007-0103-5|
|Abstract:||Several 4-substituted 1,3,5-triazino[1,2-a]benzimidazol-2-amines were prepared via cyclization of 2-benzimidazolylguanidine with various reactants. The prototropic tautomerism in the obtained dihydro analogs was investigated. According to the NMR data, the 3,4-dihydro form was found to predominate in DMSO solutions. All tested compounds inhibited the activity of mammalian dihydrofolate reductase. The most active compound was 4,4-dimethyl-3,4- dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine (IC50 = 10.9 mM). © 2007 Springer Science+Business Media, Inc.|
|Source Title:||Pharmaceutical Chemistry Journal|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 23, 2018
checked on Sep 28, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.