Studies on the swelling of composite disintegrant - methylcellulose films

Abstract

Methylcellulose (MC) films swell rapidly on contact with water. Swelling rate decreases with increase in the viscosity of the MC. Disintegrants such as Polyplasdone (PVPP) and Ac-Di-Sol when present in the MC film buffer the swelling action of MC. The order of swelling for various viscosity MC in PVPP/MC composite films is similar to that of plain MC films but in the case of Ac-Di-Sol/MC composite films the swelling order is reversed. Swelling of MC films is related to the disintgration time of the tablets containing the MC.