Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/106354
Title: Spray drying as a process for microencapsulation and the effect of different coating polymers
Authors: Wan, L.S.C. 
Heng, P.W.S. 
Chia, C.G.H.
Issue Date: 1992
Source: Wan, L.S.C.,Heng, P.W.S.,Chia, C.G.H. (1992). Spray drying as a process for microencapsulation and the effect of different coating polymers. Drug Development and Industrial Pharmacy 18 (9) : 997-1011. ScholarBank@NUS Repository.
Abstract: Microencapsulation of theophylline drug particles was carried out by a spray drying technique using an aqueous system. Comparison was made between the use of a solution and a suspension feed. The spray dried products obtained from a suspension feed were encapsulated and have better flowability. Various polymers, hydroxypropylmethylcellulose acetate succinate (HPMCAS), hydroxypropylmethylcellulose (HPMC), methylcellulose (MC) and sodium carboxymethylcellulose (NaCMC) were studied to evaluate their spray-coating properties. The results showed that drug release from the coated products was dependent on the hydrophilicity of the polymer. NaCMC, which is more hydrophilic, gelled faster and retarded the drug release more effectively. HPMC and MC produced products with similar dissolution profiles and flow properties. Spray coating with HPMCAS was unsuccessful. The polymers also affect the size and cohesiveness of the products. Smaller size particles which are more cohesive cause agglomeration and delay release of the drug.
Source Title: Drug Development and Industrial Pharmacy
URI: http://scholarbank.nus.edu.sg/handle/10635/106354
ISSN: 03639045
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

38
checked on Feb 17, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.