Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejmech.2006.12.012
Title: Quinone reductase induction activity of methoxylated analogues of resveratrol
Authors: Zhang, W.
Go, M.L. 
Keywords: Chemopreventive activity
Induction of quinone reductase
Methoxylated stilbenes
Resveratrol
Issue Date: Jun-2007
Citation: Zhang, W., Go, M.L. (2007-06). Quinone reductase induction activity of methoxylated analogues of resveratrol. European Journal of Medicinal Chemistry 42 (6) : 841-850. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejmech.2006.12.012
Abstract: Agents that induce the activity of phase II enzymes play an important role in intervening with the carcinogenic process at the initiation stage. Resveratrol is well known for its chemopreventive activity against major stages of carcinogenesis. In this study, several methoxylated analogues of resveratrol were synthesized and evaluated for their ability to induce the activity of the phase II enzyme quinone reductase (QR). Methoxy groups serve to increase lipophilicity and improve metabolic stability. Compared to resveratrol, analogues with ortho-methoxy substituents were found to be more potent inducers of QR and to exert their activity in a qualitatively different manner. The greater induction activities associated with these stilbenoids serve as a useful starting point for the design of improved chemopreventive agents. © 2007 Elsevier Masson SAS. All rights reserved.
Source Title: European Journal of Medicinal Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/106286
ISSN: 02235234
DOI: 10.1016/j.ejmech.2006.12.012
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