Please use this identifier to cite or link to this item: https://doi.org/10.3109/02652048.2011.559284
Title: Polyethyleneimine-modified pectin beads for colon-specific drug delivery: In vitro and in vivo implications
Authors: Das, S.
Chaudhury, A.
Ng, K.-Y. 
Keywords: bead
calcium-pectinate
colon-specific
polyethyleneimine
resveratrol
Issue Date: Jun-2011
Citation: Das, S., Chaudhury, A., Ng, K.-Y. (2011-06). Polyethyleneimine-modified pectin beads for colon-specific drug delivery: In vitro and in vivo implications. Journal of Microencapsulation 28 (4) : 268-279. ScholarBank@NUS Repository. https://doi.org/10.3109/02652048.2011.559284
Abstract: Calcium-pectinate (Ca-pectinate) beads have shown immense potential as colon-specific drug carrier. However, Ca-pectinate itself is unable to prevent its swelling/degradation in the upper gastro-intestinal (GI) conditions. Hence, polyethyleneimine (PEI) was added in the cross-linking solution to strengthen the Ca-pectinate network. Resveratrol was used as a model drug due to its promising therapeutic activity towards several colonic diseases. Beads were prepared by varying cross-linking solution pH and other formulation variables. The effects of these formulation variables were investigated on the bead's characteristics. Furthermore, surface morphology, drug-polymer interaction, stability, and in vivo pharmacokinetic study of the optimized formulation were performed. The optimized PEI-modified beads prevented drug release in the upper GI conditions, while released the drug in simulated colonic fluid. Furthermore, in vivo pharmacokinetics studies in rats demonstrated delayed appearance of drug in blood after oral administration. The optimized Ca-pectinate beads demonstrated both in vitro and in vivo colon-specific drug release. © 2011 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Source Title: Journal of Microencapsulation
URI: http://scholarbank.nus.edu.sg/handle/10635/106226
ISSN: 02652048
DOI: 10.3109/02652048.2011.559284
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