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|Title:||Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones|
|Citation:||Sriwilaijaroen, N.,Liu, M.,Go, M.-L.,Wilairat, P. (2006-07). Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones. Southeast Asian Journal of Tropical Medicine and Public Health 37 (4) : 607-612. ScholarBank@NUS Repository.|
|Abstract:||Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.|
|Source Title:||Southeast Asian Journal of Tropical Medicine and Public Health|
|Appears in Collections:||Staff Publications|
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