Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/106223
Title: Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones
Authors: Sriwilaijaroen, N.
Liu, M.
Go, M.-L. 
Wilairat, P.
Issue Date: Jul-2006
Citation: Sriwilaijaroen, N.,Liu, M.,Go, M.-L.,Wilairat, P. (2006-07). Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones. Southeast Asian Journal of Tropical Medicine and Public Health 37 (4) : 607-612. ScholarBank@NUS Repository.
Abstract: Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture.
Source Title: Southeast Asian Journal of Tropical Medicine and Public Health
URI: http://scholarbank.nus.edu.sg/handle/10635/106223
ISSN: 01251562
Appears in Collections:Staff Publications

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