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https://scholarbank.nus.edu.sg/handle/10635/106223
| Title: | Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones | Authors: | Sriwilaijaroen, N. Liu, M. Go, M.-L. Wilairat, P. |
Issue Date: | Jul-2006 | Citation: | Sriwilaijaroen, N.,Liu, M.,Go, M.-L.,Wilairat, P. (2006-07). Plasmepsin II inhibitory activity of alkoxylated and hydroxylated chalcones. Southeast Asian Journal of Tropical Medicine and Public Health 37 (4) : 607-612. ScholarBank@NUS Repository. | Abstract: | Sixteen antimalarial alkoxylated and hydroxylated chalcones were tested for their ability to inhibit recombinant plasmepsin II in vitro. The best inhibitory compounds had either a chloro or dimethylamino group at the 4-position of phenyl ring A in the chalcone template. Combination of the chalcones with chloroquine showed additivity or mild antagonism of Plasmodium falciparum K1 growth in culture. | Source Title: | Southeast Asian Journal of Tropical Medicine and Public Health | URI: | http://scholarbank.nus.edu.sg/handle/10635/106223 | ISSN: | 01251562 |
| Appears in Collections: | Staff Publications |
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