Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2006.04.110
Title: Pim-1 kinase expression during murine mammary development
Authors: Gapter, L.A. 
Magnuson, N.S.
Ng, K.-y. 
Hosick, H.L.
Keywords: Breast
Growth and development
Kinase
Mammary cell line
P21CIP/Waf1
Pim-1
Progesterone
Issue Date: 7-Jul-2006
Citation: Gapter, L.A., Magnuson, N.S., Ng, K.-y., Hosick, H.L. (2006-07-07). Pim-1 kinase expression during murine mammary development. Biochemical and Biophysical Research Communications 345 (3) : 989-997. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2006.04.110
Abstract: Pim-1 kinase phosphorylates substrates whose activities are linked to proliferation, survival, differentiation, and apoptosis. Although pim-1 is induced by hormones and cytokines, the hormonal control and contribution of Pim-1 to mammary gland development have not been evaluated. We examined Pim-1 expression in mammary cell lines, investigated whether Pim-1 levels could be altered in breast epithelia by mammogenic hormones, and evaluated Pim-1 expression during mammary development. We found that Pim-1 was elevated in most mammary carcinoma cell lines and progesterone increased Pim-1 protein to some extent in non-tumorigenic mammary epithelia. Pim-1 expression in situ was consistent with the documented profile of progesterone activity in mouse mammary glands. Pim-1 nuclear localization correlated with cytoplasmic distribution for its substrate, p21CIP/Waf1, and we found that Pim-1 and p21 associate in vitro. Our results suggest that Pim-1 expression may be regulated by progesterone during mammary development and Pim-1 associates with p21 in mammary epithelial cells. © 2006 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/106222
ISSN: 0006291X
DOI: 10.1016/j.bbrc.2006.04.110
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

14
checked on Jul 17, 2018

WEB OF SCIENCETM
Citations

13
checked on Jun 27, 2018

Page view(s)

103
checked on Jul 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.