Please use this identifier to cite or link to this item:
|Title:||O-Substituted derivatives of pralidoxime: Muscarinic properties and protection against soman effects in rats|
|Source:||Loke, W.-K., Sim, M.-K., Go, M.-L. (2002-05-10). O-Substituted derivatives of pralidoxime: Muscarinic properties and protection against soman effects in rats. European Journal of Pharmacology 442 (3) : 279-287. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-2999(02)01548-0|
|Abstract:||O-Substituted aldoximes of the cholinesterase reactivator pralidoxime (O-methyl 1, O-benzyl 2, O-propynyl 3 and O-butynyl 4 derivatives) were synthesized and found to exhibit strong binding affinities for muscarinic receptors in rat brain, heart and submandibulary glands. The aldoximes were noncompetitive antagonists of acetylcholine-induced contraction of the guinea pig ileum. A good correlation was observed between binding affinity and pKB. Weak anticholinesterase activities were observed for these compounds. When given intracerebroventricularly into conscious rats before soman administration (0.9 LD50, subcutaneously), the aldoximes, like atropine but not pralidoxime, protected against respiratory depression (3,4) and bradycardia (2). No protection against soman-induced pressor effects was noted. The protective effects of these aldoximes may be the outcome of compensatory mechanisms, of which the cholinergic receptor agonist and antagonist properties of these compounds may be important. © 2002 Elsevier Science B.V. All rights reserved.|
|Source Title:||European Journal of Pharmacology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 15, 2018
WEB OF SCIENCETM
checked on Feb 6, 2018
checked on Feb 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.