Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1743-7563.2011.01464.x
Title: Management of tumor lysis syndrome with a single fixed dose of rasburicase in Asian lymphoma patients: A case series and literature review
Authors: Chiang, J.
Chan, A. 
Lian, T.
Tay, K.
Quek, R.
Tao, M.
Lim, S.T.
Keywords: Asian
Electrolyte disturbances
Lymphoma
Rasburicase
Tumor lysis syndrome
Issue Date: Dec-2011
Citation: Chiang, J., Chan, A., Lian, T., Tay, K., Quek, R., Tao, M., Lim, S.T. (2011-12). Management of tumor lysis syndrome with a single fixed dose of rasburicase in Asian lymphoma patients: A case series and literature review. Asia-Pacific Journal of Clinical Oncology 7 (4) : 351-356. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1743-7563.2011.01464.x
Abstract: Aim: Recently, a number of studies have demonstrated the effectiveness of a single reduced dose of rasburicase for the management of tumor lysis syndrome (TLS) in adults. Whether Asian lymphoma patients similarly respond to a single dose of rasburicase is currently unknown. We aim to assess the efficacy of a single dose rasburicase in preventing TLS in Asian lymphoma patients. Methods: This was a single-center case series of adult lymphoma patients at high risk of TLS who received a single fixed dose of rasburicase. Patients had to have their uric acid, serum creatinine, lactate dehydrogenase and electrolytes monitored for at least 24-48h post-administration. Results: Eleven patients were identified. Majority were Chinese (91%), male (64%) and with a median age of 61years (range 41-84). All had at least two risk factors for developing TLS. Ten patients received a 6-mg dose and one received 4.5mg. Prior to rasburicase administration, the mean uric acid level was 835μmol/L (range 318-1237μmol/L) and the level 24-h post-administration was 186μmol/L (range 30-653μmol/L) (P
Source Title: Asia-Pacific Journal of Clinical Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/106120
ISSN: 17437555
DOI: 10.1111/j.1743-7563.2011.01464.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

8
checked on May 15, 2018

WEB OF SCIENCETM
Citations

6
checked on May 15, 2018

Page view(s)

38
checked on May 18, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.