Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.nano.2011.02.001
Title: Liposome formulation of co-encapsulated vincristine and quercetin enhanced antitumor activity in a trastuzumab-insensitive breast tumor xenograft model
Authors: Wong, M.-Y.
Chiu, G.N.C. 
Keywords: Breast cancer
Liposomes
Quercetin
Trastuzumab
Vincristine
Issue Date: Dec-2011
Citation: Wong, M.-Y., Chiu, G.N.C. (2011-12). Liposome formulation of co-encapsulated vincristine and quercetin enhanced antitumor activity in a trastuzumab-insensitive breast tumor xenograft model. Nanomedicine: Nanotechnology, Biology, and Medicine 7 (6) : 834-840. ScholarBank@NUS Repository. https://doi.org/10.1016/j.nano.2011.02.001
Abstract: Hormone- and trastuzumab-insensitive breast cancer has limited and ineffective clinical treatment options. This study sought to develop a liposome formulation containing a synergistic combination of vincristine and quercetin, with prolonged drug circulation times and coordinated drug release in vivo, to develop effective treatments against this subtype of breast cancer. The 2:1 molar ratio of vincristine/quercetin showed strong synergism in the hormone- and trastuzumab-insensitive JIMT-1 cells. Liposome co-encapsulation prolonged plasma circulation of the two drugs and maintained the synergistic drug ratio in vivo. Furthermore, the co-encapsulated liposome formulation demonstrated the most effective tumor growth inhibition in the JIMT-1 human breast tumor xenograft in comparison with vehicle control, free quercetin, free vincristine and free vincristine/quercetin combinations. Specifically, only the co-encapsulated liposome formulation exhibited significant antitumor activity at two-thirds of the maximum tolerated dose of vincristine, without significant body weight loss in the animals. From the Clinical Editor: In this study, a novel liposome formulation containing a synergistic combination of vincristine and quercetin was utilized in the treatment of breast cancer. Prolonged drug circulation times and coordinated drug release characterize this effective treatment, which may find its way to clinical applications in the near future. © 2011 Elsevier Inc.
Source Title: Nanomedicine: Nanotechnology, Biology, and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/106115
ISSN: 15499634
DOI: 10.1016/j.nano.2011.02.001
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