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https://doi.org/10.1080/02652030802368757
| Title: | Isolation and identification of hydroxythiohomosildenafil in herbal dietary supplements sold as sexual performance enhancement products | Authors: | Li, L. Low, M.-Y. Aliwarga, F. Teo, J. Ge, X.-W. Zeng, Y. Bloodworth, B.C. Koh, H.-L. |
Keywords: | Adulteration Erectile dysfunction Hydroxythiohomosildenafil PDE-5 inhibitors |
Issue Date: | 2009 | Citation: | Li, L., Low, M.-Y., Aliwarga, F., Teo, J., Ge, X.-W., Zeng, Y., Bloodworth, B.C., Koh, H.-L. (2009). Isolation and identification of hydroxythiohomosildenafil in herbal dietary supplements sold as sexual performance enhancement products. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 26 (2) : 145-151. ScholarBank@NUS Repository. https://doi.org/10.1080/02652030802368757 | Abstract: | An unknown compound is detected and isolated from two herbal dietary supplements bought on the internet. The structure of the unknown compound is elucidated using ESI-MS/MS, NMR, UV and IR. The compound, named hydroxythiohomosildenafil, is identified as an analogue of sildenafil in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety, and a hydroxyethyl group instead of a methyl group is attached to the piperazinyl nitrogen. It is the first report of this compound being detected in herbal dietary supplements. The UV, IR and completely assigned NMR data of hydroxythiohomosildenafil is recorded. | Source Title: | Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment | URI: | http://scholarbank.nus.edu.sg/handle/10635/106096 | ISSN: | 0265203X | DOI: | 10.1080/02652030802368757 |
| Appears in Collections: | Staff Publications |
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