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https://doi.org/10.2174/187231207783221402
| Title: | In vitro metabolism of leflunomide by mouse and human liver microsomes. | Authors: | Chan, E.C. New, L.S. |
Issue Date: | Dec-2007 | Citation: | Chan, E.C.,New, L.S. (2007-12). In vitro metabolism of leflunomide by mouse and human liver microsomes.. Drug metabolism letters 1 (4) : 299-305. ScholarBank@NUS Repository. https://doi.org/10.2174/187231207783221402 | Abstract: | Leflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated alpha-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively. | Source Title: | Drug metabolism letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/106039 | ISSN: | 18723128 | DOI: | 10.2174/187231207783221402 |
| Appears in Collections: | Staff Publications |
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