Please use this identifier to cite or link to this item: https://doi.org/10.2174/187231207783221402
Title: In vitro metabolism of leflunomide by mouse and human liver microsomes.
Authors: Chan, E.C. 
New, L.S. 
Issue Date: Dec-2007
Citation: Chan, E.C.,New, L.S. (2007-12). In vitro metabolism of leflunomide by mouse and human liver microsomes.. Drug metabolism letters 1 (4) : 299-305. ScholarBank@NUS Repository. https://doi.org/10.2174/187231207783221402
Abstract: Leflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated alpha-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively.
Source Title: Drug metabolism letters
URI: http://scholarbank.nus.edu.sg/handle/10635/106039
ISSN: 18723128
DOI: 10.2174/187231207783221402
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

6
checked on Nov 16, 2018

Page view(s)

30
checked on Oct 26, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.