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|Title:||In vitro metabolism of leflunomide by mouse and human liver microsomes.|
|Authors:||Chan, E.C. |
|Citation:||Chan, E.C.,New, L.S. (2007-12). In vitro metabolism of leflunomide by mouse and human liver microsomes.. Drug metabolism letters 1 (4) : 299-305. ScholarBank@NUS Repository. https://doi.org/10.2174/187231207783221402|
|Abstract:||Leflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated alpha-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively.|
|Source Title:||Drug metabolism letters|
|Appears in Collections:||Staff Publications|
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