Fluidized bed granulation with PVP K90 and PVP K120

Abstract

The characteristics and growth mechanics of fluidized bed granules are dependent both on process variables and the grades of PVP binders used. Generally, an increase in the concentration, spraying rate and volume of binder solution caused an increase in granule size and a decrease in size distribution. These two factors will in turn affect the poured and tapped densities of granules. Granules prepared with PVP K90 solution appeared to grow by primary and secondary agglomeration to give an aggregate structure. Granules prepared with PVP K120 solution were formed through snowballing as the primary agglomeration process. This occurred at low binder solution concentration with secondary agglomeration taking place when the concentration of PVP K120 solution was increased.