Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2005.06.026
Title: Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model
Authors: Saw, C.L.L.
Heng, P.W.S. 
Chin, W.W.L.
Soo, K.C.
Olivo, M.
Keywords: Chick chorioalllantoic membrane
Formulation
Hypericin
N-Methyl pyrrolidone
Photodynamic therapy
Vasculature
Issue Date: 8-Jul-2006
Source: Saw, C.L.L., Heng, P.W.S., Chin, W.W.L., Soo, K.C., Olivo, M. (2006-07-08). Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model. Cancer Letters 238 (1) : 104-110. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2005.06.026
Abstract: Hypericin (HY) was examined for photodynamic therapy (PDT)-induced vascular damage using the chick chorioallantoic membrane (CAM) model. Clinically, plasma protein was used to solubilize HY. Upon binding to albumin, free HY available to be transported through the membrane may be limited. Hence, formulations containing a biocompatible solvent, N-Methyl pyrrolidone (NMP), have the potential to enhance HY delivery into solid tumors. At suitable concentrations, NMP and/or light irradiation did not produce antivascular damage. Hypericin-PDT effects showed to be HY and NMP concentrations-dependent. These findings indicate that NMP is a promising solvent and penetration enhancer for HY-PDT clinical applications. © 2005 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/105923
ISSN: 03043835
DOI: 10.1016/j.canlet.2005.06.026
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