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|Title:||Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model|
|Keywords:||Chick chorioalllantoic membrane|
|Source:||Saw, C.L.L., Heng, P.W.S., Chin, W.W.L., Soo, K.C., Olivo, M. (2006-07-08). Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model. Cancer Letters 238 (1) : 104-110. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2005.06.026|
|Abstract:||Hypericin (HY) was examined for photodynamic therapy (PDT)-induced vascular damage using the chick chorioallantoic membrane (CAM) model. Clinically, plasma protein was used to solubilize HY. Upon binding to albumin, free HY available to be transported through the membrane may be limited. Hence, formulations containing a biocompatible solvent, N-Methyl pyrrolidone (NMP), have the potential to enhance HY delivery into solid tumors. At suitable concentrations, NMP and/or light irradiation did not produce antivascular damage. Hypericin-PDT effects showed to be HY and NMP concentrations-dependent. These findings indicate that NMP is a promising solvent and penetration enhancer for HY-PDT clinical applications. © 2005 Elsevier Ireland Ltd. All rights reserved.|
|Source Title:||Cancer Letters|
|Appears in Collections:||Staff Publications|
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