Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/105902
Title: Effects of mefloquine on the release of marker enzymes from the rat liver crude lysosomal fraction
Authors: Go, M.L. 
Lee, H.S.
Issue Date: 1990
Source: Go, M.L.,Lee, H.S. (1990). Effects of mefloquine on the release of marker enzymes from the rat liver crude lysosomal fraction. Japanese Journal of Pharmacology 53 (2) : 195-199. ScholarBank@NUS Repository.
Abstract: The effects of the antimalarial agent mefloquine on the release of marker enzymes, acid phosphatase and beta glucuronidase, from the rat liver lysosomes in a crude lysosomal preparation were investigated and compared with that of chloroquine whose membrane effects have been well-documented in the literature. At 10 μM, mefloquine decreased significantly the release of marker enzymes when compared to the control, but at the higher concentrations of 100 μM and 500 μM, it markedly accelerated the release of enzymes. This suggested that mefloquine exerted a concentration-dependent biphasic effect of membrane stabilization and labilization. In comparison, chloroquine diminished the release of enzymes over the concentration range of 10-500 μM, that is showing a membrane stabilizing effect similar to other reports. Since serum levels of 1.6-3.2 μM are reported after a weekly dose of mefloquine, the present results suggest that a predominant stabilization effect should prevail under these conditions. However, higher drug concentrations may result in labilization with undesirable consequences.
Source Title: Japanese Journal of Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/105902
ISSN: 00215198
Appears in Collections:Staff Publications

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