Please use this identifier to cite or link to this item:
|Title:||Effects of mefloquine on the isolated chick biventer cervicis and rat phrenic nerve hemidiaphragm preparations|
|Citation:||Lee, H.S.,Go, M.L. (1991). Effects of mefloquine on the isolated chick biventer cervicis and rat phrenic nerve hemidiaphragm preparations. Archives Internationales de Pharmacodynamie et de Therapie 312 : 158-167. ScholarBank@NUS Repository.|
|Abstract:||The effects of the antimalarial agent mefloquine on skeletal muscle and its neurotransmission were investigated on the isolated chick biventer cervicis and rat phrenic nerve hemidiaphragm. At concentrations of 64, 128 and 257 μM, mefloquine reduced twitch contraction responses to nerve stimulation, and inhibited carbachol- and KCl-induced contractures of avian muscle. Qualitatively similar responses were observed for chloroquine (257 μM) and quinine (512 μM ) but the inhibitory effects of mefloquine were more pronounced and less readily reversible. On the rat phrenic nerve hemidiaphragm, mefloquine (50, 75 and 100 μM) inhibited twitch contractions stimulated indirectly via the nerve. When nerve transmission has been blocked with α-bungarotoxin, mefloquine inhibited twitch responses obtained by direct stimulation of the hemidiaphragm. The present findings indicate that its prime action seems to be on muscle contractility, possibly by inhibiting excitation-contraction coupling.|
|Source Title:||Archives Internationales de Pharmacodynamie et de Therapie|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 29, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.