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|Title:||Effects of mefloquine on Ca2+ uptake and release by dog brain microsomes|
|Source:||Lee, H.S.,Go, M.L. (1996). Effects of mefloquine on Ca2+ uptake and release by dog brain microsomes. Archives Internationales de Pharmacodynamie et de Therapie 331 (3) : 221-231. ScholarBank@NUS Repository.|
|Abstract:||The effects of the antimalarial drug, mefloquine, on the uptake and release of Ca2+ by crude microsomes from dog brain were investigated using a spectrophotometric method. Mefloquine inhibited the inositol-1,4,5-phosphate (IP3)-induced Ca2+ release with an IC50 of 42 μM, but was a weaker inhibitor of the uptake of Ca2+ into the vesicles (IC50: 272 μM). These effects of mefloquine are in contrast to its actions on Ca2+ uptake and release by skeletal muscle microsomes, where its predominant effect was seen to be the inhibition of Ca2+ uptake into the vesicles. Mefloquine was found to be more potent than quinine as a specific inhibitor of Ca2+ release from IP3-sensitive stores in dog brain microsomes. The possibility of the drug affecting cellular IP3-linked signal transduction processes should be considered.|
|Source Title:||Archives Internationales de Pharmacodynamie et de Therapie|
|Appears in Collections:||Staff Publications|
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